The future of orthopaedics is computational
COSI is a research lab led by Professor Stefano A. Bini, MD. We use machine learning, population-scale clinical data, biomechanical simulation, and surgical robotics to change how hip and knee surgery is studied, planned, and performed.
Surgical robots log every cut and every gap. Record networks hold the histories of tens of millions of patients. A tendon repair can be simulated before the incision is made.
The raw material for a new kind of surgery already exists. Our work turns it into evidence, tools, and technique.
Research programs
Five connected programs: clinical data raises mechanical questions, models inform new techniques, and those techniques generate new data.
Population-scale evidence
Screening entire classes of drugs and exposures against musculoskeletal disease in the records of tens of millions of patients.
Computational biomechanics
Patient-specific simulations of surgical repairs: how a construct shares load, and where it fails, before the operating room.
Robotics and intraoperative data
Treating the robot's plan as a prediction, and testing it against what the surgeon actually finds.
AI agents in the clinical workflow
Agentic software for evidence synthesis, cohort building, and documentation, held to a clinical standard.
Surgical technique innovation
New approaches and repair strategies, taken from anatomic insight to the operating room, then measured.
Selected work
A medication-wide association study of hip and knee osteoarthritis across 50 drugs
Screening dozens of medications at once for their association with osteoarthritis in a federated clinical dataset.
Load-sharing mechanics of scaffold augmentation in gluteus medius repair
How a scaffold redistributes load across a tendon repair, modeled patient by patient.
Native coronal deformity and gap prediction in robotic-assisted knee replacement
Why the robot underpredicts the medial gap as native deformity increases.
Get involved
Students & researchers
Take on research with real clinical impact, publish it, and work alongside talented engineers and clinicians.
How to joinIndustry
Pilot technology with the surgeons who will use it and a lab that will measure whether it works.
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